This led to a high coefficient of inbreeding over successive generations. The cumulative effect of these unions concentrated recessive genetic traits, transforming what was once a calculated political strategy into a hereditary curse that manifested in the final generation of Spanish Habsburgs.
Charles II Reign Dynastic Collapse: The Inbreeding Catastrophe
His reign serves as a pivotal case study in population genetics, illustrating how royal convenience can lead to dynastic collapse. Studies suggest that Charles II had an inbreeding coefficient of approximately 0.
The Genetic Legacy of the Spanish Habsburgs The Habsburg dynasty, which ruled Spain from the 16th to the early 18th century, practiced strategic marriages to maintain power across Europe. His reign, which lasted from 1665 to 1700, was defined by severe physical and mental disabilities directly attributable to generations of intermarriage within the family.
Charles II Reign Dynastic Collapse: The Inbreeding Catastrophe
He suffered from mandibular prognathism, a condition that caused a severe underbite so pronounced it interfered with his speech and ability to chew. Contemporary Medical Analysis Modern geneticists have analyzed historical records and portraits of the Spanish Habsburgs to calculate their inbreeding coefficients.
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