Long-acting injectable treatments, which replace daily pills with doses administered every few months, are also reducing the viral reservoir size, offering a new tactical approach to managing the virus and potentially paving the way for cure strategies. Recent trials have shown that bNAbs can effectively suppress the virus for months, sometimes longer than oral ART.
Blood Transplant HIV Cure: How Stem Cell Transplants Led to Functional Cures
Current antiretrovirals cannot penetrate these reservoirs, allowing the virus to remain silent. These laboratory-engineered antibodies can target multiple strains of HIV, blocking the virus from entering cells and marking infected cells for destruction by the immune system.
Gene editing tools like CRISPR-Cas9 are being refined to cut out HIV DNA from the genome. By suppressing the virus to undetectable levels, ART prevents disease progression and eliminates the risk of sexual transmission, a concept known as U=U (Undetectable = Untraceable).
Blood Transplant HIV Cure: How Stem Cell Transplants Led to Functional Cure
For the millions living with HIV today, this research offers more than just a scientific milestone; it promises a future free from the burden of daily medication and the stigma associated with the condition. The Berlin and London Patients: Lessons Learned The only two individuals considered functionally cured of HIV—the Berlin and London Patients—achieved this status through stem cell transplants to treat cancer.
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