A viable cure may involve a two-step process: first, using "shock and kill" or gene editing to flush the virus from reservoirs, and second, using immunotherapy or a stem cell transplant to keep it at bay. Additionally, novel immunotherapies are being designed to train the immune system to recognize and destroy infected cells.
Engineered Antibodies: A New HIV Treatment Strategy Bringing New Hope
Recent trials have shown that bNAbs can effectively suppress the virus for months, sometimes longer than oral ART. By suppressing the virus to undetectable levels, ART prevents disease progression and eliminates the risk of sexual transmission, a concept known as U=U (Undetectable = Untraceable).
Any attempt to cure HIV must address this hidden sanctuary. The Berlin and London Patients: Lessons Learned The only two individuals considered functionally cured of HIV—the Berlin and London Patients—achieved this status through stem cell transplants to treat cancer.
Engineered Antibodies Offer New Hope in HIV Treatment
The procedure involved replacing their immune systems with donor cells lacking the CCR5 co-receptor, a key protein HIV uses to enter cells. Gene editing tools like CRISPR-Cas9 are being refined to cut out HIV DNA from the genome.
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