" This results in massive vasodilation, increased vascular permeability, and myocardial depression. The irony is that while the body attempts to kill the bug, the physiological damage caused by the immune response itself is often the direct cause of the hypotension and organ failure.
Protocol for Identifying the Source of Infection in Septic Shock
Viral pathogens, such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can also induce a cytokine storm reminiscent of bacterial sepsis, highlighting that the shock etiology extends beyond traditional bacterial paradigms. This specific subset is characterized by persistent hypotension requiring vasopressors to maintain a mean arterial pressure of 65 mmHg or greater and having a serum lactate level greater than 2 mmol/L despite adequate volume resuscitation.
The etiology is not singular; rather, it is a spectrum of events starting with pathogen invasion and ending with cardiovascular collapse. Predisposing Medical Conditions Chronic illnesses weaken the body's reserve and alter the shock etiology.
Protocol for Pinpointing the Primary Infection Source
Hospital-acquired infections, particularly those involving multidrug-resistant organisms, are increasingly implicated in severe cases of shock etiology. Fungal infections, particularly in immunocompromised hosts, can lead to similar hemodynamic collapse.
More About Septic shock etiology
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