" This results in massive vasodilation, increased vascular permeability, and myocardial depression. Predisposing Medical Conditions Chronic illnesses weaken the body's reserve and alter the shock etiology.
How Host Genetic Factors Influence Septic Shock Risk
While bacteria remain the most common culprit, other microorganisms can also precipitate this life-threatening condition. Furthermore, underlying health conditions significantly modify the shock etiology.
Viral pathogens, such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can also induce a cytokine storm reminiscent of bacterial sepsis, highlighting that the shock etiology extends beyond traditional bacterial paradigms. This specific subset is characterized by persistent hypotension requiring vasopressors to maintain a mean arterial pressure of 65 mmHg or greater and having a serum lactate level greater than 2 mmol/L despite adequate volume resuscitation.
How Host Genetic Factors Influence Septic Shock Risk
Hospital-acquired infections, particularly those involving multidrug-resistant organisms, are increasingly implicated in severe cases of shock etiology. Certain primary sites are statistically more likely to lead to the hemodynamic instability characteristic of shock.
More About Septic shock etiology
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