" This results in massive vasodilation, increased vascular permeability, and myocardial depression. Initially, a pro-inflammatory cascade is launched to combat the pathogen.
Clinical Precipitants Management Guide
Host Genetic and Physiological Factors Not everyone exposed to the same pathogen will develop septic shock, indicating that host factors are central to the etiology. The fundamental drivers behind this catastrophic progression are the systemic inflammatory responses triggered by invading pathogens and the dysregulated host response, which ultimately leads to widespread organ dysfunction and failure.
Bacterial Sources Gram-negative bacteria, such as *Escherichia coli* and *Klebsiella pneumoniae*, are notorious for releasing endotoxins like lipopolysaccharide (LPS), which trigger a massive cytokine release. Gram-positive organisms, including *Staphylococcus aureus* and *Streptococcus pneumoniae*, produce exotoxins that similarly wreak havoc on the vascular system.
Clinical Precipitants Management Guide
Furthermore, underlying health conditions significantly modify the shock etiology. Hospital-acquired infections, particularly those involving multidrug-resistant organisms, are increasingly implicated in severe cases of shock etiology.
More About Septic shock etiology
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