The correct nucleotide is then reloaded, allowing synthesis to continue without propagating the error. The palm domain of the enzyme closes around the reacting groups, creating an environment that excludes water.
How DNA Polymerase Selects the Correct Nucleotides for Accurate Replication
Understanding this mechanism reveals how life maintains its genetic code across generations. This oxygen atom attacks the alpha-phosphate of the incoming dNTP, displacing the beta and gamma phosphates as pyrophosphate.
Concurrently, a proton is released, maintaining the acid-base balance of the immediate environment. This enzyme does not act randomly; it reads the existing strand and selects only those building blocks that can form correct base pairs.
How DNA Polymerase Selects the Correct Nucleotide for Synthesis
Adenine is positioned to pair with thymine, and guanine is positioned to pair with cytosine. This oxygen atom attacks the alpha-phosphate of the incoming dNTP, displacing the beta and gamma phosphates as pyrophosphate.
More About How does dna polymerase add nucleotides
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