The result is the formation of a phosphodiester bond that links the new nucleotide to the chain. This enzyme does not act randomly; it reads the existing strand and selects only those building blocks that can form correct base pairs.
DNA Polymerase Induced Fit: How the Enzyme Selects and Adds Nucleotides
DNA polymerase interacts with sliding clamps and other accessory proteins that tether it to the template. Understanding this mechanism reveals how life maintains its genetic code across generations.
Concurrently, a proton is released, maintaining the acid-base balance of the immediate environment. DNA polymerase adds nucleotides through a precise, template-directed mechanism that ensures genetic information is copied with remarkable fidelity.
DNA Polymerase Induced Fit: How the Enzyme Selects and Adds Nucleotides
The coordination ensures that the replication fork advances smoothly as the enzyme continuously adds nucleotides to the leading and lagging strands. Each incoming dNTP carries three phosphates, and the cleavage of the pyrophosphate bond provides the driving force for bond formation.
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