5-ARIs may lead to a decreased libido, erectile dysfunction, or reduced semen volume, and there is a small risk of elevated prostate-specific antigen (PSA) levels, which can mask the detection of prostate cancer. Commonly Prescribed Alpha-Blockers Tamsulosin (Flomax) Terazosin (Hytrin) Doxazosin (Cardura) Alfuzosin (Uroxatral) While effective for symptom relief, these medications do not shrink the prostate.
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These medications work by targeting the biological processes that cause the gland to enlarge, providing relief from bothersome symptoms such as a weak stream and frequent urination. This relaxation widens the urethra, allowing urine to flow more easily and reducing the strain of urination.
How Alpha-Blockers Work to Relieve Symptoms Alpha-blockers are a common first-line treatment for BPH symptoms. Alpha-blockers may cause dizziness, headaches, or retrograde ejaculation, where semen enters the bladder instead of exiting the body.
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5-Alpha-Reductase Inhibitors: Targeting Prostate Growth Unlike alpha-blockers, 5-alpha-reductase inhibitors (5-ARIs) attack the root cause of prostate growth. Medication is most effective when paired with specific lifestyle modifications.
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