Release Mechanism and Pathway Once secreted, glucagon follows a direct route through the circulatory system. Because the islets of Langerhans are richly vascularized, the hormone enters the portal venous system immediately upon release.
How Regulation of Glucagon Release Works in the Pancreas
During periods of stress or intense physical activity, neural signals prompt the alpha cells to increase output. This portal circulation carries glucagon directly to the liver, which is the primary target organ.
When blood glucose begins to drop, these alpha cells are activated to release stored glucagon directly into the bloodstream. Alpha Cells: The Producers of Glucagon Specifically, glucagon is synthesized and secreted by alpha cells, which are a major component of the islets of Langerhans.
How Regulation of Glucagon Release Works in the Pancreas
Interaction with Other Systems The secretion of glucagon is intricately linked to the autonomic nervous system, particularly the sympathetic branch responsible for the "fight or flight" response. Glucagon is a critical hormone for maintaining glucose balance, yet its precise origin often remains unclear.
More About Where is glucagon released from
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