Some patients report abdominal pain or vomiting during flares, which can occasionally lead to misdiagnosis as an acute surgical abdomen. These attacks are remarkably stereotypic for the individual, making the pattern a powerful diagnostic clue.
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While a genetic predisposition is strongly implicated, with the condition often clustering in families, the specific environmental triggers that initiate the cyclical fever remain a subject of intense investigation. 2°F) or higher and persists for an average of three to five days.
These cytokines, which are critical for mounting an immune response, appear to be inappropriately activated in susceptible individuals. A careful and systematic evaluation is crucial to ensure that a treatable underlying condition is not overlooked.
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Potential triggers include viral infections, stress, and immune system activation. Recurrent infections, such as streptococcal pharyngitis or chronic tonsillitis, must be ruled out, as they can present with similar fever and throat symptoms.
More About Pfeiffer 2 syndrome
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