The Pelger-Huet anomaly disrupts this process, resulting in neutrophils with nuclei that appear bilobed or round, lacking the typical fine chromatin structure. In a healthy individual, the nucleus of a mature neutrophil resembles a multi-lobed structure, typically with 2 to 5 distinct segments connected by thin strands of chromatin.
Pelger-Huet Anomaly Blood Film Review: Identifying Key Nuclear Morphology
Misdiagnosis as a myelodysplastic syndrome is a potential pitfall, which is why a thorough review of the blood film and family history is essential before rendering a final conclusion. The hereditary variant is a benign, autosomal dominant trait caused by mutations affecting the lamin B receptor (LBR) gene.
Neutrophils are the most abundant white blood cells in human blood, acting as the first line of defense against bacterial and fungal infections. Hematologists look for the pathognomonic "dumbbell" or "pince-nez" nuclei in neutrophils, which are the hallmark of the condition.
Pelger-Huet Anomaly Blood Film Review Guide: Key Nuclear Features to Identify
This morphological feature is most often an inherited trait, passed down in an autosomal dominant pattern, and typically does not interfere with the cell’s function. For this reason, the hereditary form is generally considered a benign variant rather than a disease, standing in stark contrast to the acquired forms that may arise due to underlying medical conditions.
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