Common Side Effects and Initial Management Most individuals taking metoclopramide will experience some common, generally mild side effects. Akathisia, a feeling of inner restlessness and an inability to sit still, and parkinsonism, with symptoms like tremor and rigidity, are other key EPS manifestations.
Metoclopramide Tardive Dyskinesia Treatment Options
It can also affect the limbs, causing choreiform movements that resemble fidgeting or dancing. In many cases, these common side effects can be managed by adjusting the dosage or timing of administration under a doctor's supervision, and they often subside as the body acclimates.
If a patient on long-term therapy develops signs of TD, the primary step in treatment is to discontinue metoclopramide as soon as clinically feasible. Because of this risk, regulatory agencies strongly advise against using metoclopramide for more than 12 weeks.
Metoclopramide Tardive Dyskinesia Treatment Options
Treatment for established TD is challenging and may involve medications like VMAT2 inhibitors (valbenazine, deutetrabenazine) to help manage the involuntary movements. These reactions typically occur as the body adjusts to the medication and are often manageable without discontinuing treatment.
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