This massive release of inflammatory mediators, such as tumor necrosis factor-alpha and interleukins, causes blood vessels to dilate excessively and become more permeable. Septic Shock and the Hypertension Paradox In the later stages of sepsis, particularly septic shock, the picture often becomes mixed.
Can Infection Trigger Sudden Hypertension Through Inflammatory Response and Vascular Changes
Fluid retention mediated by RAAS attempts to restore blood volume. The Inflammatory Cascade and Blood Pressure Dysregulation The core issue linking sepsis and hypertension begins with the overwhelming inflammatory response known as a cytokine storm.
This paradoxical hypertension can be misleading, as it occurs alongside ongoing organ dysfunction and tissue hypoperfusion, creating a dangerous clinical scenario that requires careful hemodynamic assessment. Careful fluid management, source control of infection, and balancing the need for inotropic support are central to stabilizing blood pressure regardless of the direction of the abnormality.
Can Infection Trigger Sudden Blood Pressure Surges Through Inflammatory Response
Vasoconstriction in non-essential vascular beds raises peripheral resistance. This damage may predispose survivors to chronic hypertension, underscoring the importance of long-term cardiovascular follow-up for this population.
More About Can sepsis cause hypertension
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