Males and females are equally likely to inherit the dominant gene and be affected. Carrier Status and Genetic Counseling Individuals who possess one copy of a recessive gene mutation but do not have the disease are known as carriers.
Understanding Autosomal Recessive Inheritance in Brittle Bone Disease
Looking Ahead: Genetic Testing and Research. Autosomal Recessive Inheritance While less common, some severe forms of brittle bone disease follow an autosomal recessive pattern of inheritance.
Because the defective gene dominates the healthy one, the physical traits of the disease will likely be expressed. Genetic counseling plays a vital role for families with a history of brittle bone disease or for couples where one partner knows they are a carrier.
Autosomal Recessive Inheritance Patterns and Examples
Family History and Probability If one parent has the condition, each child has a 1 in 2 chance of inheriting the mutation. This flaw disrupts the body's ability to produce the strong, resilient collagen that acts as the scaffolding for bones, leading to the characteristic fragility associated with the condition.
More About How is brittle bone disease inherited
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