This results in a sustained elevation in cell counts, even in the absence of a current infection. Steroids, such as prednisone, are well-known for stimulating the release of stored white cells from the bone marrow, leading to a transient increase.
How Autoimmune Conditions Attack White Blood Cells and Disrupt Blood Health
Events such as major surgery, severe burns, or even intense physical exertion can trigger a leukocytic response. Conditions such as rheumatoid arthritis, lupus, or inflammatory bowel disease keep the immune system in a heightened state of alert.
Myeloproliferative disorders, where the bone marrow produces too many cells, can also present with leukocytosis. The causes range from the mundane, like a small unnoticed cut, to the serious, such as a systemic infection or a hematologic disorder.
How Autoimmune Conditions Attack White Blood Cells and Drive Leukocytosis
The physiological stress of these events mimics an infection, prompting the release of cortisol and other hormones that stimulate the bone marrow. When the brain detects a threat, it signals the bone marrow to release more of these cells into the bloodstream.
More About Causes of high white blood cell count
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